EGCG 95%

Epigallocatechin gallate is a potent polyphenolic flavonoid which is found as a component of tea. It exhibits antioxidant, antimutagenic, antitumor and anti-inflammatory properties, thereby contributing to the health-beneficial actions. It finds potential use as a drug candidate in the pharmaceutical, cosmetic, and nutritional fields.

(-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-ß and amaloid plaques in mice. This compound has neuroprotective properties.

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Product Packaging	0.5-5kg/ bag
Synonyms	TEA CATECHIN; (-)-Epigallocatechin-3-O-gallate; EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG90
EINECS	479-560-7
Content Specification	95% (HPLC)
Molecular Formula	C22H18O11
Formula Weight	458.37
Melting Point	222-224°C
Boiling Point	-175.5°C(C=1, EtOH)
Alpha	D-185 ±2°(ethanol)
Density	1.90±0.1 g/cm3(Predicted)
Plant origin	Green tea leaves
Form	Solid
Color	White to Light Brown
Solubility	H2O: ≥5mg/mL, clear
Water Solubility	Soluble in ethanol, dimethyl formamide, water.
Refractive Index	-84° (C=2, EtOH)
pKa	7.75±0.25(Predicted)
Detection method	HPLC
InChIKey	WMBWREPUVVBILR-WIYYLYMNSA-N
LogP	0.639 (est)
Safety Statements	24/25
WGK Germany	2
RTECS	KB5200000
F	10-23
HS Code	29339900
Toxicity	LD50 oral in mouse: 2170mg/kg
Definition	ChEBI: (-)-epigallocatechin 3-gallate is a gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. It has a role as an antineoplastic agent, an antioxidant, a Hsp90 inhibitor, a neuroprotective agent, a plant metabolite, a geroprotector and an apoptosis inducer. It is a gallate ester, a polyphenol and a member of flavans. It is functionally related to a (-)-epigallocatechin.
Biochem/physiol Actions	(-)-Epigallocatechin gallate (EGCG), an antioxidant polyphenol flavonoid exerts anti-tumor properties by inhibiting telomerase and DNA methyltransferase activity.
Anticancer Research	EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin.
Storage	2-8°C