Freeze-Drying Technology for Dietary Supplement Development

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Aprofood's freeze-drying technology is extensively employed in the domain of dietary supplements, streamlining nutrient preservation and formulation enhancement. It accelerates the retention of sensitive ingredients, refines product stability, and fosters breakthroughs in nutritional science and health innovation. Through this sophisticated approach, Aprofood is committed to offering more effective and dependable solutions for supplement development and consumer wellness.

Fig 1. Freeze-drying process. Fig.1 Freeze-drying process - low temperature freezing. (Shutterstock)

Features of Freeze-Drying Technology

Freeze-drying takes place at low temperatures and is therefore particularly suitable for many heat-sensitive substances. For example, proteins, microorganisms and the like will not be denatured or lose their biological vitality.
When drying at low temperature, the loss of some volatile components in the substance is very small, which is suitable for food drying.
During freeze-drying, the growth of microorganisms and the action of enzymes cannot be carried out, so the original properties can be maintained.
Since drying is carried out in a frozen state, the volume remains almost unchanged, the original structure is maintained, and no concentration occurs.
The dried substance is loose and porous, spongy, and dissolves rapidly and completely after adding water, restoring the original character almost immediately.
Since the drying is carried out under vacuum, there is very little oxygen, so some substances that are easy to oxidize are protected.

Materials Suitable for Freeze-Drying Technology

Herbal Extracts

This method safeguards the vital elements in herbs.

Probiotics

Freeze-drying keeps probiotics inactive at low temperatures, extending their shelf life.

Vitamins

This approach optimally secures vitamin activity, preventing damage during processing.

Proteins

Freeze-drying preserves protein integrity, ensuring quick mixing and nutritional benefits in liquids.

Enzymes

The process allows enzymes to dry without losing their activity due to heat.

Freeze-Drying Process for Dietary Supplements

The products undergo pre-freezing, using both rapid and gradual methods, which benefits the subsequent processes.
After a constant-temperature, reduced-pressure phase, the process continues under fixed pressure and gradually increased temperature, effectively removing most of the moisture from the product.
Additional drying removes both adsorbed and bound water, ensuring that the freeze-dried powder stays dry and minimizes the risk of absorbing moisture again.

Types of Freeze-Drying Protectants

Freeze-drying protectants ensure a smooth process and help regulate osmotic pressure. During both freeze-drying and drying, they prevent active compounds from degrading, stop effective components from being lost with water vapor to aid product formation, inhibit oxidation during processing and storage, and adjust the pH of biological products.

Sugars

Monosaccharides, oligosaccharides, and polysaccharides

Alcohols

Sugar alcohols including glycerol, sorbitol, mannitol, and similar compounds

Amino Acids

Examples include proline, histidine, arginine, lysine, among others

Salts

Primarily used as pH buffers to maintain the solution's pH balance

Aprofood's freeze-drying technology establishes a strong basis for exceptional dietary supplement quality. Our skilled team integrates advanced science to transform every project into a standard of innovation and dependability, guaranteeing optimal stability and effectiveness. Reach out to us today to learn how Aprofood's advanced technology can make your dietary supplement products shine in the market and achieve enduring success.

For Research Use Only.

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How Did You Hear About Us?

* We utilize freeze-dried flash dispersion technology to create dietary supplement tablets, ideal for bulk purchases. Our OEM & ODM services cater to researchers, organizations, and companies pursuing innovative supplement formulations.

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Thank you for showing interest in Aprofood’s innovative freeze-dried flash dispersion technology tailored for dietary supplements. We are ready to provide advanced products, services, and technical assistance. If you wish to explore a partnership, please leave a message, and we will gladly reach out to you.